Centers of Biomedical Research Excellence augment and strengthen institutional biomedical research capabilities by expanding and developing biomedical faculty research capability through support of a multidisciplinary center led by a peer-reviewed, NIH-funded investigator with expertise central to the theme of the grant proposal.
Came to the UPR Medical Sciences Campus from the Massachusetts General Hospital / Harvard University in 2014.
Alpha-7 nAChR: Potential Therapeutic Target for Obesity Induced Cognitive Decline
Epigenetic control of transcription dynamics in long-term alcohol neuroadaptation
Role of microglial α7nAChR in diet induced brain inflammation.
Institute of Neurobiology, University of Puerto Rico, Medical Sciences Campus
Establishing an experimental model for probing the neural and molecular basis of abnormally repetitive behavior
Polymorphism in neuroplasticity-related genes and its association with anxiety and depressive symptoms severity in Caribbean Hispanic patients
Role of Nicotinic Alpha 7 Autoreceptors in Striatal Cholinergic Interneurons
Chromatin remodeling during butterfly brain development
Ex vivo and in vivo models of Gulf War Illness Allow for Mechanistic Studies and the Search for Antidotes
Synthesis of Biological Active Amino Derivatives and Multi-target Drugs for the Treatment of Alzheimer’s Disease
Xylazine effects on morphine-induced prefrontal cortex neuroplasticity
Age-dependent involvement of inflammation associated receptors in hippocampal plasticity and neuroprotection after an ischemic insult
Lipid Dendrimer Nanoparticles for the Encapsulation of Brain-Derived Neurotrophic Factor and Simvastatin as a Non-Invasive Approach to Promote Neuroplasticity
Nuclear G-coupled Kinin-B2 Receptors in a Human hCMEC/D3 Blood Brain Barrier Cell title: Nuclear G-coupled B2 receptor
The program hosted the four members of its External Advisory Committee: Dr. Karen Echeverri (Marine Biological Lab, Woods Hole MA), Dr. Steven Treistman (UMass School of Medicine), Dr. José Lemos (UMass School of Medicine), and Dr. Jan Merino Ramírez (Seattle Children’s Hospital). UPR administrative personnel included Dr. Yasmin Pedrogo (Dean of Academic Affairs), Dr. Annabell…
Details
Dr. José A. Lasalde, COBRE Center for Neuroplasticity Program Director, was awarded an EnTRUST Life Sciences Accelerator grant from the Puerto Rico Science Trust. Through the Technology Transfer Office, EnTRUST supports researchers across Puerto Rico in moving discoveries from the lab to real-world impact with mentorship, structure, and strategic guidance
Details
The work is a collaborative effort between several campuses: the UPR-Cayey, UPR-Carolina and UPR-MSC Integrated Informatics Services facility RCMI-RCC-IIS in collaboration with the Institute of Neurobiology.
Localization of Cholecystokinin/Sulfakinin Neuropeptides in Biomphalaria glabrata, an Intermediate Host for Schistosomiasis. J Comp Neurol. 2025 Jan;533(1):e70016. doi: 10.1002/cne.70016. PMID: 39825709; PMCID: PMC11841659.
A conserved gastropod withdrawal circuit in Biomphalaria glabrata, an intermediate host for schistosomiasis. J Neurophysiol. 2024 May 1;131(5):903-913. doi: 10.1152/jn.00390.2023. Epub 2024 Mar 13. PMID: 38478883; PMCID: PMC11383391.
The FMRF-NH2 gated sodium channel of Biomphalaria glabrata: Localization and expression following infection by Schistosoma mansoni
