The 8th Annual COBRE Retreat and Assessment Activity.

The COBRE center for Neuroplasticity at the University of Puerto Rico will co-sponsor the 8th anual COBRE Retreat and Assessment Activity. We will start at 12 PM on May 11th. Enter the following link to join Meeting ID: 847 3299 4055.  Passcode: 546225. We look forward to your participation.  


An interdisciplinary multi-campus center

Will implement improvements to the research infrastructure of Puerto Rico and will support a critical mass of investigators with shared scientific interests in the neurosciences.

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Centers of Biomedical Research Excellence augment and strengthen institutional biomedical research capabilities by expanding and developing biomedical faculty research capability through support of a multidisciplinary center led by a peer-reviewed, NIH-funded investigator with expertise central to the theme of the grant proposal.


Came to the UPR Medical Sciences Campus from the Massachusetts General Hospital / Harvard University in 2014.

Alpha-7 nAChR: Potential Therapeutic Target for Obesity Induced Cognitive Decline

Epigenetic control of transcription dynamics in long-term alcohol neuroadaptation

Role of microglial α7nAChR in diet induced brain inflammation.

Assistant Professor

Institute of Neurobiology, University of Puerto Rico, Medical Sciences Campus

Pilots Projects

Establishing an experimental model for probing the neural and molecular basis of abnormally repetitive behavior

Polymorphism in neuroplasticity-related genes and its association with anxiety and depressive symptoms severity in Caribbean Hispanic patients

Role of Nicotinic Alpha 7 Autoreceptors in Striatal Cholinergic Interneurons

Chromatin remodeling during butterfly brain development

Collaborative Seeds Projects

Dr. Nadezhda Sabeva

& Dr. Antonio H. Martins:

Ex vivo and in vivo models of Gulf War Illness Allow for Mechanistic Studies and the Search for Antidotes

& Dr. José Colón:

Synthesis of Biological Active Amino Derivatives and Multi-target Drugs for the Treatment of Alzheimer’s Disease

Dr. Priscila Sanabria

& Dr. Carlos Jiménez:

Xylazine effects on morphine-induced prefrontal cortex neuroplasticity

Dr. Yancy Ferrer

& Dr. Valance Washington:

Age-dependent involvement of inflammation associated receptors in hippocampal plasticity and neuroprotection after an ischemic insult

Dr. Luis Negrón

& Dr. José Rivera:

Lipid Dendrimer Nanoparticles for the Encapsulation of Brain-Derived Neurotrophic Factor and Simvastatin as a Non-Invasive Approach to Promote Neuroplasticity

Dr. Yancy Ferrer

& Dr. Antonio H. Martins:

Nuclear G-coupled Kinin-B2 Receptors in a Human hCMEC/D3 Blood Brain Barrier Cell title: Nuclear G-coupled B2 receptor

Request for Application or Funding Opportunities






Research news

Institute faculty participate in Puerto Rico INBRE – COBRE Symposium

Faculty speakers from the Institute of Neurobiology presented their research at the Puerto Rico INBRE – COBRE Symposium, May 19-20, 2017.  Speakers in the Neurocience session included (left to right) Dr. Amaya Miquelajauregui, Dr. Kristin Branson (Keynote, Janelia Research Campus), Dr. Andrew Seeds, and Dr. Cristina Velåzquez.  Dr. Mark Miller served as session moderator. 

Recents Publications

July 30, 2020

Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls

July 30, 2020

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under

July 30, 2020

Neuroprotection Against Diisopropylfluorophosphate in Acute Hippocampal Slices. Neurochem Res. 2015 Oct;40(10):2143-51. doi: 10.1007/s11064-015-1729-4. Epub 2015 Oct 5. PubMed PMID: