Dr. Antonio H. Martins



As a postdoctoral fellow at the Biochemistry Department- University of Sao Paulo- Brazil, I carried out experiments to examine the role of the principal peptide of the kallikrein-kinin system named bradykinin and its receptor B2-kinin receptor during neural progenitor differentiation and maturation. As an Associate Professor at the University of Puerto Rico (UPR), I started several projects involved the kallikrein-kinin system and renin-angiotensin projects focused on neuroprotection. I recently published that the kallikrein-kinin system is involved in muscle differentiation. Bradykinin is a peptide that has many functions, including neuroprotection against N-methyl-D-aspartate and organophosphates. Moreover, we have shown that activation of the B2 kinin receptor can open the blood-brain barrier (BBB) and is involved in the lung inflammation triggered by COVID-19. COBRE is helping me to understand the function of the expression of the B2-kinin receptor in the nucleus of specific cells. In summary, during my time in Puerto Rico, I have been able to collaborate with the University of Central Caribe, and various investigators from the United States and always have been passionate about working on the kallikrein-kinin system.