“Establishment of a multi-user high-performance MALDI ToF/ToF mass at the Molecular Science Research Center”



  • TheMALDI-7090 mass spectrometer will be used to measure the levels of neuropeptides across the chronology of infection, from its  initial stage of  penetration by S mansoni miracidia to the stage of shedding cercariae after approximately 25-30 days.
  • The goal of this project is to use matrix-assisted laser desorption/ionization, time-of-flight mass  spectrometry (MALDI-ToF-MS) to investigate the changes in neuropeptide release during the development of alcohol tolerance.
  • Our group uses MALDI-ToF for the simultaneous analysis of mixed glycans released from our ENV protein vaccine candidates. This glycan composition analysis allows for the development of upstream and downstream processes for the large-scale production of ENV Using this methodology, it is possible to evaluate the effect of culture conditions and purification schemes on the glycosylation of ENV.